Professor of Surgery, OSU Director of Cardiovascular Tissue Engineeering Program, NCH

Thoracic Surgery

Toshiharu Shin'Oka is an expert in the field of Thoracic Surgery. He received 8 awards: "Takao Award", "Blue Ribbon 1st Place Poster", "Medical Award", "Funding Award", "Japanese Society of Pediatric Cardiology and Cardiac Surgery Award", "Thoracic Surgery Award", "The Young Investigators Award" and "Research Award". Toshiharu Shin'Oka has written publications. He has 68 publications published with PubMed. The lastest publication is: 'Effects of a monoclonal antibody to P-selectin on recovery of neonatal lamb hearts after cold cardioplegic ischemia.'

Publications

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• Beyond Burst Pressure: Initial Evaluation of the Natural History of the Biaxial Mechanical Properties of Tissue Engineered Vascular Grafts in the Venous Circulation Us...
• First evidence that bone marrow cells contribute to the construction of tissue-engineered vascular autografts in vivo.
• Surgery for unilateral absence of pulmonary artery using autologous tissue.
• Extracardiac total cavopulmonary connection using a tissue-engineered graft.
• The influence of pH strategy on cerebral and collateral circulation during hypothermic cardiopulmonary bypass in cyanotic patients with heart disease: results of a ran...
• Establishing right ventricle-pulmonary artery continuity by autologous tissue: an alternative approach for prosthetic conduit repair.
• [Clinical results of tissue-engineered vascular autografts seeded with autologous bone marrow cells].
• A successful total cavopulmonary connection conversion 13 years after an anatomic repair for tricuspid atresia IIc with severe pulmonary resistance.
• Autopericardial patch tracheoplasty for tracheal stenosis after arterial switch operation.
• The tissue-engineered vascular graft using bone marrow without culture.
• Midterm clinical result of tissue-engineered vascular autografts seeded with autologous bone marrow cells.
• One-stage intracardiac repair in combination with external stenting of the trachea and right bronchus for tetralogy of Fallot with an absent pulmonary valve and trache...
• Successful application of pulmonary arterial patch for coronary angioplasty late after arterial switch operation.
• Hemodilutional anemia impairs neurologic outcome after cardiopulmonary bypass in a piglet model.
• Anatomic correction of congenitally corrected transposition and its close cousins.
• Outcomes of definitive surgical repair for congenitally corrected transposition of the great arteries or double outlet right ventricle with discordant atrioventricular...
• Clinical results of staged repair with complete unifocalization for pulmonary atresia with ventricular septal defect and major aortopulmonary collateral arteries.
• Evaluation of tissue-engineered vascular autografts.
• Conversion to total cavopulmonary connection 9 years after closure of a large ventricular septal defect.
• Successful extracardiac total cavo pulmonary connection (TCPC) after external tracheobronchial stenting for tracheobronchomalacia.
• Successful explantation of ventricular assist device for systemic ventricular assistance in a patient with congenitally corrected transposition of the great arteries.
• Therapeutic angiogenesis using tissue engineered human smooth muscle cell sheets.
• A novel method to reduce pericardial adhesion: a combination technique with hyaluronic acid biocompatible membrane.
• Novel anti-adhesive pericardial substitute for multistage cardiac surgery.
• Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis.
• Subaortic stenosis associated with systolic anterior motion.
• Characterization of long-term cultured c-kit+ cardiac stem cells derived from adult rat hearts.
• Simultaneous use of argatroban and heparin during cardiopulmonary bypass.
• Tissue-engineered vascular grafts form neovessels that arise from regeneration of the adjacent blood vessel.
• Comparison of Human Bone Marrow Mononuclear Cell Isolation Methods for Creating Tissue-Engineered Vascular Grafts: Novel Filter System Versus Traditional Density Centr...
• Determining the fate of seeded cells in venous tissue-engineered vascular grafts using serial MRI.
• Effects of autologous platelet concentrate reinfusion after open heart surgery in patients with congenital heart disease.
• An arterial switch operation for a concordant crisscross heart with the complete transposition of the great arteries.
• Successful clinical application of tissue-engineered graft for extracardiac Fontan operation.
• Long-term histologic findings in pulmonary arteries reconstructed with autologous pericardium.
• Successful application of tissue engineered vascular autografts: clinical experience.
• [Repair for atrioventricular valve regurgitation using autologous pericardium: report of a case].
• Tissue engineering lamb heart valve leaflets.
• [Valvuloplasty for mitral regurgitation associated with acromegaly: report of a case].
• [Successful correction of incomplete endocardial cushion defects in an elderly patient].
• [Surgical treatment of transposition of the great arteries with intact ventricular septum associated with left ventricular outflow obstruction].
• [Reoperations of extracardiac valved conduit for congenital cardiac defects].
• [Successful two-staged Jatene operation for severe right ventricular dysfunction and tricuspid regurgitation after Senning operation--a case report].
• Blockade of selectin-mediated leukocyte adhesion improves postischemic function in lamb hearts.
• Intermittent whole-body perfusion with "somatoplegia' versus blood perfusate to extend duration of circulatory arrest.
• Higher hematocrit improves cerebral outcome after deep hypothermic circulatory arrest.
• Evaluation of a pulsatile pediatric ventricular assist device in an acute right heart failure model.
• Tissue engineering of cardiovascular structures.
• Effects of oncotic pressure and hematocrit on outcome after hypothermic circulatory arrest.
• Near-infrared spectrophotometry of the brain in cardiovascular surgery.
• High-volume continuous hemofiltration during cardiopulmonary bypass attenuates pulmonary dysfunction in neonatal lambs after deep hypothermic circulatory arrest.
• Effects of a monoclonal antibody to P-selectin on recovery of neonatal lamb hearts after cold cardioplegic ischemia.
• Oxygenation strategy and neurologic damage after deep hypothermic circulatory arrest. I. Gaseous microemboli.
• Oxygenation strategy and neurologic damage after deep hypothermic circulatory arrest. II. hypoxic versus free radical injury.
• A novel sialyl Lewis X analog attenuates cerebral injury after deep hypothermic circulatory arrest.
• [Pulmonary outflow tract reconstruction with autologous tissue during the Ross procedure: right ventricular characteristics in mid-term follow-up].
• Utility of near-infrared spectroscopic measurements during deep hypothermic circulatory arrest.
• [Cerebral oxygenation during non-blood prime cardiopulmonary bypass in congenital heart surgery].
• [Heparin monitoring during cardiopulmonary bypass in congenital heart surgery].
• Definite improvement in left ventricular function at six years after the Takeuchi procedure.
• Transplantation of a tissue-engineered pulmonary artery.
• Surgical intervention for anomalous origin of the left coronary artery from the pulmonary artery: the Tokyo experience.
• [Cryopreservation of vascular mixed cell for tissue engineering in cardiovascular surgery].
• Double-Switch operation for congenitally corrected transposition.
• Tissue-engineered vascular autograft: inferior vena cava replacement in a dog model.
• Coarctation of the aorta and ventricular septal defect: should we perform a single-stage repair?
• Double switch operation for superior-inferior ventricles.

Schools

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• Hiroshima University

Doctors Specialties

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• General Surgery
• Thoracic Surgery

Accepted Insurances

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Awards

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• Takao Award
• Blue Ribbon 1st Place Poster
• Medical Award
• Funding Award
• Japanese Society of Pediatric Cardiology and Cardiac Surgery Award
• Thoracic Surgery Award
• The Young Investigators’ Award
• Research Award

Education

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• Boston Children's Hospital

Hospital

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• Ohio State University Wexner Medical Center
• Nationwide Children's Hospital

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