Chief, Laboratory of Biochemical Physiology Cardiovascular Pulmonary Branch NHLBI, NIH
Pulmonology
Dr. Vincent C. Manganiello, MD
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Dr. Vincent C. Manganiello practices Pulmonology. He researched medicine at Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is one of the top medical schools in the US. Johns Hopkins University School of Medicine is ranked 3/29 in Research/PrimaryCare. Doctor Vincent C. Manganiello, MD is a published doctor as well. He has 101 publications published. The latest was: Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I.
Publications
- Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis.
- Regulation of Sarcoplasmic Reticulum Ca2+ ATPase 2 (SERCA2) Activity by Phosphodiesterase 3A (PDE3A) in Human Myocardium: PHOSPHORYLATION-DEPENDENT INTERACTION OF PDE3...
- Tuberous sclerosis complex 2 loss of heterozygosity in patients with lung disease and cancer.
- Serum Apolipoprotein A-I and Large HDL Particles are Positively Correlated with FEV in Atopic Asthma.
- Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.
- Advances in targeting cyclic nucleotide phosphodiesterases.
- Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms.
- A Role for Phosphodiesterase 3B in Acquisition of Brown Fat Characteristics by White Adipose Tissue in Male Mice.
- Phosphodiesterase Type 3A Regulates Basal Myocardial Contractility Through Interacting With Sarcoplasmic Reticulum Calcium ATPase Type 2a Signaling Complexes in Mouse ...
- Resveratrol as a calorie restriction mimetic: therapeutic implications.
- Phosphodiesterase 3A (PDE3A) deletion suppresses proliferation of cultured murine vascular smooth muscle cells (VSMCS) via inhibition of mitogen activated protein kina...
- Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets.
- Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity.
- Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism.
- Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice.
- Importance of cAMP-response element-binding protein in regulation of expression of the murine cyclic nucleotide phosphodiesterase 3B (Pde3b) gene in differentiating 3T...
- Effect of adipocyte beta3-adrenergic receptor activation on the type 2 diabetic MKR mice.
- Isoforms of cyclic nucleotide phosphodiesterase PDE3 and their contribution to cAMP hydrolytic activity in subcellular fractions of human myocardium.
- Adenovirus-mediated overexpression of murine cyclic nucleotide phosphodiesterase 3B.
- Identification of promoter elements in 5'-flanking region of murine cyclic nucleotide phosphodiesterase 3B gene.
- Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology.
- Dual effects of pituitary adenylate cyclase-activating polypeptide and isoproterenol on lipid metabolism and signaling in primary rat adipocytes.
- Systematic search for single nucleotide polymorphisms in the 5' flanking region of the human phosphodiesterase 3B gene: absence of evidence for major effects of identi...
- Isoforms of cyclic nucleotide phosphodiesterase PDE3A in cardiac myocytes.
- Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin.
- Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracel...
- Methods to study phosphorylation and activation of the hormone-sensitive adipocyte phosphodiesterase type 3B in rat adipocytes.
- Expression of phosphodiesterase 3 in rat submandibular gland cell lines.
- Phosphodiesterase 3 as a potential target for therapy of malignant tumors in the submandibular gland.
- Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A expressed in vascular smooth-muscle myocytes.
- Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family.
- Membrane localization of cyclic nucleotide phosphodiesterase 3 (PDE3). Two N-terminal domains are required for the efficient targeting to, and association of, PDE3 wit...
- Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorpo...
- Functions of the N-terminal region of cyclic nucleotide phosphodiesterase 3 (PDE 3) isoforms.
- Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor.
- Cardiac type cGMP-inhibited phosphodiesterase (PDE3A) gene structure: similarity and difference to adipocyte type PDE3B gene.
- Down-regulation of cyclic-nucleotide phosphodiesterase 3B in 3T3-L1 adipocytes induced by tumour necrosis factor alpha and cAMP.
- Cyclic nucleotide phosphodiesterases (PDEs): diverse regulators of cyclic nucleotide signals and inviting molecular targets for novel therapeutic agents.
- Cyclic nucleotide phosphodiesterases (PDE) 3 and 4 in normal, malignant, and HTLV-I transformed human lymphocytes.
- Evidence for the presence of several phosphodiesterase isoforms in brown adipose tissue of Zucker rats: modulation of PDE2 by the fa gene expression.
- Phosphorylation and activation of phosphodiesterase type 3B (PDE3B) in adipocytes in response to serine/threonine phosphatase inhibitors: deactivation of PDE3B in vitr...
- IL-3 and IL-4 activate cyclic nucleotide phosphodiesterases 3 (PDE3) and 4 (PDE4) by different mechanisms in FDCP2 myeloid cells.
- Mechanisms of inhibition of lipolysis by insulin, vanadate and peroxovanadate in rat adipocytes.
- Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I.
- Expression and characterization of deletion recombinants of two cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE-3).
- Cyclic nucleotide PDE-3. Quantitation of PDE-3A and -3B mRNAs in rat tissues by RNase protection assay.
- Insulin-induced translocation of protein kinase B to the plasma membrane in rat adipocytes.
- Phosphorylation and activation of hormone-sensitive adipocyte phosphodiesterase type 3B.
- Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase o...
- Regulation of hormone-sensitive lipase activity in adipose tissue.
- Regulation of protein kinase B in rat adipocytes by insulin, vanadate, and peroxovanadate. Membrane translocation in response to peroxovanadate.
- Differential expression of cyclic nucleotide phosphodiesterase 3 and 4 activities in human T cell clones specific for myelin basic protein.
- Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3).
- Protein kinase A-dependent activation of PDE4 (cAMP-specific cyclic nucleotide phosphodiesterase) in cultured bovine vascular smooth muscle cells.
- cGMP-inhibited phosphodiesterases (PDE3 gene family).
- Characterization of the cDNA and gene encoding human PDE3B, the cGIP1 isoform of the human cyclic GMP-inhibited cyclic nucleotide phosphodiesterase family.
- Expression and activity of low Km, cGMP-inhibited cAMP phosphodiesterase in cardiac and skeletal muscle.
- Characterization of two recombinant PDE3 (cGMP-inhibited cyclic nucleotide phosphodiesterase) isoforms, RcGIP1 and HcGIP2, expressed in NIH 3006 murine fibroblasts and...
- Differential expression of cGMP-inhibited cyclic nucleotide phosphodiesterases in human hepatoma cell lines.
- Type III cyclic nucleotide phosphodiesterases and insulin action.
- Identification of the site in the cGMP-inhibited phosphodiesterase phosphorylated in adipocytes in response to insulin and isoproterenol.
- Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family).
- Molecular cloning of the rat adipocyte hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase.
- Cytosolic and sarcoplasmic reticulum-associated low Km, cGMP-inhibited cAMP phosphodiesterase in mammalian myocardium.
- Identification of the phosphorylation site in vitro for cAMP-dependent protein kinase on the rat adipocyte cGMP-inhibited cAMP phosphodiesterase.
- Single-step affinity purification, partial structure and properties of human platelet cGMP inhibited cAMP phosphodiesterase.
- Essential role of phosphatidylinositol 3-kinase in insulin-induced activation and phosphorylation of the cGMP-inhibited cAMP phosphodiesterase in rat adipocytes. Studi...
- Roles of ATP in insulin actions.
- A novel insulin secretagogue is a phosphodiesterase inhibitor.
- Evidence for the key role of the adipocyte cGMP-inhibited cAMP phosphodiesterase in the antilipolytic action of insulin.
- Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases.
- Stimulation by insulin of a serine kinase in human platelets that phosphorylates and activates the cGMP-inhibited cAMP phosphodiesterase.
- Insulin stimulates hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase in rat brown adipose cells.
- Diversity in cyclic nucleotide phosphodiesterase isoenzyme families.
- [Semi-logarithmic volume-time diagram obtained by mathematical analysis of the flow-volume curve. Preliminary data].
- Regulation of specific forms of cyclic nucleotide phosphodiesterases in cultured cells.
- Purification and properties of calmodulin-stimulated phosphodiesterase from mammalian brain.
- Selective inhibition of two soluble adenosine cyclic 3',5'-phosphate phosphodiesterases partially purified from calf liver.
- Effects of fatty acids on activity of cGMP-stimulated cyclic nucleotide phosphodiesterase from calf liver.
- Selective regulation by pertussis toxin of insulin-induced activation of particulate cAMP phosphodiesterase activity in 3T3-L1 adipocytes.
- Purification and characterization of cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from calf liver. Effects of divalent cations on activity.
- Ca2+-independent cyclic GMP phosphodiesterases from rat liver and HTC hepatoma cells.
- Bradykinin stimulates phospholipid methylation, calcium influx, prostaglandin formation, and cAMP accumulation in human fibroblasts.
- Calmodulin-activated cyclic nucleotide phosphodiesterase from brain. Relationship of subunit structure to activity assessed by radiation inactivation.
- Calmodulin-activated cyclic nucleotide phosphodiesterase from brain. Changes in molecular size assessed by gel filtration and electrophoresis.
- Effects of d- and l-propranolol on the responsiveness of human fibroblasts to choleragen and prostaglandin E1.
- Protein carboxyl-methylase modifies calmodulin function.
- Modification of calmodulin function by enzymatic carboxylic methylation.
- Effect of dexamethasone on adenosine 3',5'-monophosphate content and phosphodiesterase activities in 3T3-L1 adipocytes.
- Selective effects of phosphodiesterase inhibitors on different phosphodiesterases, adenosine 3',5'-monophosphate metabolism, and lipolysis in 3T3-L1 adipocytes.
- Alterations in cyclic AMP phosphodiesterase activities during differentiation of 3T3-L1 cells.
- Complex effects of inhibitors on cyclic GMP-stimulated cyclic nucleotide phosphodiesterase.
- Hormone-sensitive particulate cAMP phosphodiesterase activity in 3T3-L1 adipocytes. Regulation of responsiveness by dexamethasone.
- Regulation of cyclic nucleotide phosphodiesterase activity.
- Regulation by bradykinin of its receptor and of receptor-mediated prostacyclin formation in cultured human fibroblasts.
- Autoregulation of bradykinin receptors and bradykinin-induced prostacyclin formation in human fibroblasts.
- Regulation of activity of purified guanylate cyclase from liver that is unresponsive to nitric oxide.
- Receptors for bradykinin in intact cultured human fibroblasts. Identification and characterization by direct binding study.
- Reversible inactivation of soluble liver guanylate cyclase by disulfides.
- Presence of autoantibody for phospholipase inhibitory protein, lipomodulin, in patients with rheumatic diseases.
Schools
Johns Hopkins University School of Medicine
Doctors Specialties
- Other
- Pediatrics
- Pulmonology
Accepted Insurances
Education
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Johns Hopkins University -
Johns Hopkins University School of Medicine
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