Distinguished Professor Emeritus
Rheumatology
Dr. William Arend, MD
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Doctor William Arend, MD practices Rheumatology. He studied medicine at Columbia University College of Physicians & Surgeons. Columbia University College of Physicians & Surgeons is a top medical college. Columbia University College of Physicians & Surgeons is ranked 8 in research and 52 in primary care medicine He over the years received 1 awards: "Elected Member". William Arend, MD has written publications. He has 99 publications published with PubMed. The lastest paper is: 'Interleukin-4 (IL-4) and IL-13 enhance the effect of IL-1beta on production of IL-1 receptor antagonist by human primary hepatocytes and hepatoma HepG2 cells: differen...'
Publications
- Essential Role for the Lectin Pathway in Collagen Antibody-Induced Arthritis Revealed through Use of Adenovirus Programming Complement Inhibitor MAp44 Expression.
- Roles of Adipocytes and Fibroblasts in Activation of the Alternative Pathway of Complement in Inflammatory Arthritis in Mice.
- Essential role of surface-bound complement factor h in controlling immune complex-induced arthritis.
- The role of interleukin-1 receptor antagonist in the prevention and treatment of disease.
- Enhancement of collagen-induced arthritis in mice genetically deficient in extracellular superoxide dismutase.
- Cytokines in the rheumatic diseases.
- Generation and characterization of mice transgenic for human IL-18-binding protein isoform a.
- Prevention of collagen-induced arthritis in mice transgenic for the complement inhibitor complement receptor 1-related gene/protein y.
- Intracellular IL-1Ra type 1 inhibits IL-1-induced IL-6 and IL-8 production in Caco-2 intestinal epithelial cells through inhibition of p38 mitogen-activated protein ki...
- Mice transgenic for intracellular interleukin-1 receptor antagonist type 1 are protected from collagen-induced arthritis.
- Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein.
- Mechanisms of effects of complement inhibition in murine collagen-induced arthritis.
- The mode of action of cytokine inhibitors.
- The balance between IL-1 and IL-1Ra in disease.
- Cytokine-induced differentiation of cultured nonadherent macrophages.
- Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice.
- Initiation of the alternative pathway of murine complement by immune complexes is dependent on N-glycans in IgG antibodies.
- IL-1, IL-18, and IL-33 families of cytokines.
- The development of anticytokine therapeutics for rheumatic diseases.
- Pathogenic complement activation in collagen antibody-induced arthritis in mice requires amplification by the alternative pathway.
- Anti-dsDNA antibody assay: high specificity and sensitivity with a filtration radioassay in comparison to low specificity with the standard ELISA.
- Rheumatoid factor seropositivity is inversely associated with oral contraceptive use in women without rheumatoid arthritis.
- Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collagen-induced arthritis.
- Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis.
- Intracellular IL-1 receptor antagonist type 1 inhibits IL-1-induced cytokine production in keratinocytes through binding to the third component of the COP9 signalosome.
- Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis.
- Role of c3a receptors, c5a receptors, and complement protein c6 deficiency in collagen antibody-induced arthritis in mice.
- Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement.
- N-?-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis.
- IL-1 family nomenclature.
- Essential role of complement mannose-binding lectin-associated serine proteases-1/3 in the murine collagen antibody-induced model of inflammatory arthritis.
- Fate of preformed immune complexes in rabbits and rhesus monkeys.
- Complement activation pathways in murine immune complex-induced arthritis and in C3a and C5a generation in vitro.
- Association of rheumatoid arthritis treatment response and disease duration with declines in serum levels of IgM rheumatoid factor and anti-cyclic citrullinated peptid...
- Serum disappearance and catabolism of homologous immunoglobulin fragments in rats.
- Autoimmune neutropenia in systemic lupus erythematosus.
- Neutrophil-binding immunoglobulin G in systemic lupus erythematosus.
- Composition and biologic properties of soluble IgG-anti-IgG immune complexes: effects of variations in the specificity of rabbit antibodies to different structural com...
- Neutral protease secretion by human monocytes. Effect of surface-bound immune complexes.
- Characterization of two species of Fc fragments obtained from rat IgG2a by prolonged papain digestion.
- Monocyte-reactive antibodies in patients with systemic lupus erythematosus.
- The innate immune system in rheumatoid arthritis.
- May 2001: 32 year old female with dural mass encircling cervical spinal cord.
- Cytokine imbalance in the pathogenesis of rheumatoid arthritis: the role of interleukin-1 receptor antagonist.
- Cytokines and cellular interactions in inflammatory synovitis.
- Physiology of cytokine pathways in rheumatoid arthritis.
- Increased production of intracellular interleukin-1 receptor antagonist type I in the synovium of mice with collagen-induced arthritis: a possible role in the resoluti...
- Production of IL-1 receptor antagonist by hepatocytes is regulated as an acute-phase protein in vivo.
- Physiologic role of interleukin-1 receptor antagonist.
- Biological role of interleukin 1 receptor antagonist isoforms.
- The human intracellular interleukin 1 receptor antagonist promoter appropriately regulates gene expression in keratinocytes and gastrointestinal epithelial cells in vivo.
- Interleukin-4 (IL-4) and IL-13 enhance the effect of IL-1beta on production of IL-1 receptor antagonist by human primary hepatocytes and hepatoma HepG2 cells: differen...
- Treatment of rheumatoid arthritis with IL-1 inhibitors.
- A unified list of acronyms for the rheumatology literature.
- The differential production of three forms of IL-1 receptor antagonist by human neutrophils and monocytes.
- Characterization of a low molecular weight isoform of IL-1 receptor antagonist.
- Interleukin-1 receptor antagonist: role in biology.
- Mouse IL-1 receptor antagonist isoforms: complementary DNA cloning and protein expression of intracellular isoform and tissue distribution of secreted and intracellula...
- Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein.
- The pathophysiology and treatment of rheumatoid arthritis.
- A uniform reference system for rheumatology journals.
- Lipopolysaccharide and Raf-1 kinase regulate secretory interleukin-1 receptor antagonist gene expression by mutually antagonistic mechanisms.
- Intracellular IL-1 receptor antagonist promoter: cell type-specific and inducible regulatory regions.
- Clinical differentiation between giant cell (temporal) arteritis and Takayasu''s arteritis.
- Levels of synovial fluid interleukin-1 receptor antagonist in rheumatoid arthritis and other arthropathies. Potential contribution from synovial fluid neutrophils.
- The human interleukin-1 receptor antagonist (IL1RN) gene is located in the chromosome 2q14 region.
- Interleukin-1 receptor antagonist.
- Enhanced production of IL-1 receptor antagonist by alveolar macrophages from patients with interstitial lung disease.
- Tumor necrosis factor-alpha induces interleukin-1 alpha and interleukin-1 receptor antagonist production by cultured human keratinocytes.
- The effects of interleukin-10 on interleukin-1 receptor antagonist and interleukin-1 beta production in human monocytes and neutrophils.
- Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis.
- Interleukin 1 receptor antagonist production in human monocytes is induced by IL-1 alpha, IL-3, IL-4 and GM-CSF.
- Peripheral blood neutrophil production of interleukin-1 receptor antagonist and interleukin-1 beta.
- IL-1 antagonism in inflammatory arthritis.
- Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids.
- Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline.
- LPS-induced expression of the human IL-1 receptor antagonist gene is controlled by multiple interacting promoter elements.
- IgG induction of IL-1 receptor antagonist production by human monocytes.
- Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis.
- Inhibiting the effects of cytokines in human diseases.
- Differential binding of human interleukin-1 (IL-1) receptor antagonist to natural and recombinant soluble and cellular IL-1 type I receptors.
- Humoral and cellular immune mechanisms of neutropenia in patients with Felty''s syndrome.
- Loss of Fc receptor activity after culture of human monocytes on surface-bound immune complexes. Mediation by cyclic nucleotides.
- The effect of complement in adherent immune complexes on Fc and C3 receptor expression in human monocytes.
- Chronic neutropenia: possible association with Sjögren's syndrome.
- Effect of immune complexes on human neutrophil phagocytic function.
- Characteristics of fibrinolytic enzyme release from human monocytes.
- Characterization of immune complexes and immunoglobulin G antibodies reactive with neutrophils in the sera of patients with Felty's syndrome.
- Induction of tissue transglutaminase in human peripheral blood monocytes.
- Spinal-fluid acidosis and the diagnosis of pulmonary encephalopathy.
- Studies on antigen-antibody complexes. II. Quantification of tissue uptake of soluble complexes in normal and complement-depleted rabbits.
- In vitro adherence of soluble immune complexes to macrophages.
- Determination of soluble immune complex molar composition and antibody association constants by ammonium sulfate precipitation.
- The effect of complement depletion on wound healing.
- The macrophage receptor for IgG: number and affinity of binding sites.
- Molecular composition and sedimentation characteristics of soluble antigen-antibody complexes.
- Nonsecretory myeloma. Immunofluorescent demonstration of paraprotein within bone marrow plasma cells.
- Characteristics of bacterial lipopolysaccharide induction of interleukin 1 synthesis and secretion by human monocytes.
Schools
Columbia University College Of Physicians and Surgeons
University Wash Hospital
Doctors Specialties
- Rheumatology
Accepted Insurances
Awards
- Elected Member
Education
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University of Washington -
Columbia University College of Physicians & Surgeons
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