Physician
Preventive Medicine
Dr. William C. Knowler, MD
William Knowler practices Preventive Medicine. He attended Harvard Medical School. Harvard Medical School is one of the top medical schools in the US. Harvard Medical School has a rank of 1 in research and a 12 in primary care William C. Knowler is a published doctor as well. He has 99 publications published. The latest was: Assessment of established HDL-C loci for association with HDL-C levels and type 2 diabetes in Pima Indians.
Publications
- Assessment of established HDL-C loci for association with HDL-C levels and type 2 diabetes in Pima Indians.
- Lifestyle and metformin ameliorate insulin sensitivity independently of the genetic burden of established insulin resistance variants in Diabetes Prevention Program pa...
- Analysis of SLC16A11 variants in 12,811 American Indians: genotype-obesity interaction for type 2 diabetes and an association with RNASEK expression.
- Urinary monocyte chemoattractant protein-1 and hepcidin and early diabetic nephropathy lesions in type 1 diabetes mellitus.
- Depressive Symptoms, Antidepressant Medication Use, and New Onset of Diabetes in Participants of the Diabetes Prevention Program and the Diabetes Prevention Program Ou...
- The Effect of Lifestyle Intervention and Metformin on Preventing or Delaying Diabetes Among Women With and Without Gestational Diabetes: The Diabetes Prevention Progra...
- A cis-eQTL in PFKFB2 is associated with diabetic nephropathy, adiposity and insulin secretion in American Indians.
- Systolic Blood Pressure Control Among Individuals With Type 2 Diabetes: A Comparative Effectiveness Analysis of Three Interventions.
- Variants associated with type 2 diabetes identified by the transethnic meta-analysis study: assessment in American Indians and evidence for a new signal in LPP.
- Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children.
- Weight maintenance from young adult weight predicts better health outcomes.
- The Look AHEAD study: a missed opportunity - Authors' Reply.
- Diabetic kidneys do deserve a lifestyle change.
- HbA1c as a Predictor of Diabetes and as an Outcome in the Diabetes Prevention Program: A Randomized Clinical Trial.
- Elevation of circulating TNF receptors 1 and 2 increases the risk of end-stage renal disease in American Indians with type 2 diabetes.
- Study design of the maycoba project: obesity and diabetes in mexican pimas.
- Impact of weight loss on ankle-brachial index and interartery blood pressures.
- Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure.
- Potential epigenetic dysregulation of genes associated with MODY and type 2 diabetes in humans exposed to a diabetic intrauterine environment: An analysis of genome-wi...
- The INFLUENCE of rare Genetic variation in SLC30A8 on diabetes incidence and beta-cell function.
- Genetic Risk of Progression to Type 2 Diabetes and Response to Intensive Lifestyle or Metformin in Prediabetic Women With and Without a History of Gestational Diabetes.
- Brain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants.
- A Genome-Wide Association Study in American Indians Implicates DNER as a Susceptibility Locus for Type 2 Diabetes Mellitus.
- Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes.
- The relationship between insulin sensitivity and maximal oxygen uptake is confounded by method of adjustment for body composition.
- Comparison of serum cystatin C, serum creatinine, measured GFR, and estimated GFR to assess the risk of kidney failure in American Indians with diabetic nephropathy.
- Preventing diabetes in American Indian communities.
- MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation.
- Four-year change in cardiorespiratory fitness and influence on glycemic control in adults with type 2 diabetes in a randomized trial: the Look AHEAD Trial.
- Can new-onset diabetes after kidney transplant be prevented?
- FTO predicts weight regain in the Look AHEAD clinical trial.
- Effect of Losartan on Prevention and Progression of Early Diabetic Nephropathy in American Indians With Type 2 Diabetes.
- Strong Parent-of-Origin Effects in the Association of KCNQ1 Variants with Type 2 Diabetes Mellitus in American Indians.
- The long-term effectiveness of a lifestyle intervention in severely obese individuals.
- Variation at the melanocortin 4 receptor gene and response to weight-loss interventions in the diabetes prevention program.
- Confirming glycemic status in the diabetes prevention program: implications for diagnosing diabetes in high risk adults.
- Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes.
- Evidence for a role of LPGAT1 in influencing BMI and percent body fat in native Americans.
- Simple anthropometrics are more correlated with health variables than are estimates of body composition in Yup'ik people.
- Variants in the LEPR Gene Are Nominally Associated With Higher BMI and Lower 24-h Energy Expenditure in Pima Indians.
- Greater impact of melanocortin-4 receptor deficiency on rates of growth and risk of type 2 diabetes during childhood compared with adulthood in Pima Indians.
- Early Renal Function Decline in Type 2 Diabetes.
- Pretransplant risk score for new-onset diabetes after kidney transplantation.
- Albuminuria and Estimated Glomerular Filtration Rate as Predictors of Diabetic End-Stage Renal Disease and Death.
- Prevention of type 2 diabetes: comment on "lifestyle modification and prevention of type 2 diabetes in overweight Japanese with impaired fasting glucose levels".
- SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians.
- A Genome-Wide Association Study of BMI in American Indians.
- Association of variants in the carnosine peptidase 1 gene (CNDP1) with diabetic nephropathy in American Indians.
- Between-monitor differences in step counts are related to body size: implications for objective physical activity measurement.
- ELMO1 variants and susceptibility to diabetic nephropathy in American Indians.
- Effect of intrauterine diabetes exposure on the incidence of end-stage renal disease in young adults with type 2 diabetes.
- Secular trends in treatment and control of type 2 diabetes in an American Indian population: a 30-year longitudinal study.
- Evaluation of A2BP1 as an obesity gene.
- Optimizing a proteomics platform for urine biomarker discovery.
- Relationship between inpatient hyperglycemia and insulin treatment after kidney transplantation and future new onset diabetes mellitus.
- Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish.
- Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians.
- Predictive value of albuminuria in American Indian youth with or without type 2 diabetes.
- Childhood obesity, other cardiovascular risk factors, and premature death.
- Change in the distribution of albuminuria according to estimated glomerular filtration rate in Pima Indians with type 2 diabetes.
- Common variation in SIM1 is reproducibly associated with BMI in Pima Indians.
- Stabilization of glucose in blood samples: why it matters.
- Childhood predictors of adult acute insulin response and insulin action.
- Maternal influence, not diabetic intrauterine environment, predicts children's energy intake.
- The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program.
- Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima...
- Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant.
- Diabetic nephropathy in American Indians, with a special emphasis on the Pima Indians.
- Value of urinary albumin-to-creatinine ratio as a predictor of type 2 diabetes in pre-diabetic individuals.
- The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: a meta-analysis involving 13,949 individuals.
- Depression, diabetes, and glycemic control in an American Indian community.
- Predictive power of sequential measures of albuminuria for progression to ESRD or death in Pima Indians with type 2 diabetes.
- Plasma glucose regulation and mortality in pima Indians.
- Childhood predictors of young-onset type 2 diabetes.
- A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array.
- TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: analysis of 3,501 individuals.
- Progression to type 2 diabetes characterized by moderate then rapid glucose increases.
- Changing patterns of type 2 diabetes incidence among Pima Indians.
- A genomewide single-nucleotide-polymorphism panel for Mexican American admixture mapping.
- Genome-wide linkage analyses to identify Loci for diabetic retinopathy.
- Identification of PVT1 as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association ...
- Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.
- Prediction of diabetic nephropathy using urine proteomic profiling 10 years prior to development of nephropathy.
- Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes.
- Albuminuria within the "normal" range and risk of cardiovascular disease and death in American Indians: the Strong Heart Study.
- Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Preventi...
- Stability of body weight in type 2 diabetes: Response to Chaudhry et al.
- Effect of youth-onset type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young and middle-aged Pima Indians.
- Electrocardiographic abnormalities predict deaths from cardiovascular disease and ischemic heart disease in Pima Indians with type 2 diabetes.
- Gestational glucose tolerance and risk of type 2 diabetes in young Pima Indian offspring.
- Trends in heart disease death rates in diabetic and nondiabetic Pima Indians.
- Habitual physical activity in children: the role of genes and the environment.
- Predominant effect of kidney disease on mortality in Pima Indians with or without type 2 diabetes.
- Early growth in offspring of diabetic mothers.
- Periodontal disease and mortality in type 2 diabetes.
- Interaction between an 11betaHSD1 gene variant and birth era modifies the risk of hypertension in Pima Indians.
- Hematocrit and the incidence of type 2 diabetes in the pima indians.
- Adiponectin concentrations are influenced by renal function and diabetes duration in Pima Indians with type 2 diabetes.
Schools
Harvard Medical School
Faulkner Hospital
Harvard School Pub Health
Doctors Specialties
- Preventive Medicine
Accepted Insurances
Education
-
Harvard Medical School
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