Physician

Obstetrics & Gynecology

Yoel Sadovsky practices Obstetrics & Gynecology. He attended The Hebrew University of Jerusalem Hadassah Medical School. Doctor Yoel Sadovsky, MD is a published doctor as well. He has 99 publications published. The latest was: A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance.

Publications

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• A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance.
• Placental Origins of Adverse Pregnancy Outcomes: Potential Molecular Targets- An Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child H...
• The expression and post-transcriptional regulation of FSTL1 transcripts in placental trophoblasts.
• Loss of inherited genomic imprints in mice leads to severe disruption in placental lipid metabolism.
• A genome-wide association study of early spontaneous preterm delivery.
• The assembly of miRNA-mRNA-protein regulatory networks using high-throughput expression data.
• Prevention of preterm birth: Harnessing science to address the global epidemic.
• The influence of ligand-activated LXR on primary human trophoblasts.
• Fatty acid binding protein-4 is expressed in the mouse placental labyrinth, yet is dispensable for placental triglyceride accumulation and fetal growth.
• C19MC microRNAs Regulate the Migration of Human Trophoblasts.
• Maternal Serum Serpin B7 Is Associated With Early Spontaneous Preterm Birth.
• NDRG1 Deficiency Attenuates Fetal Growth and the Intrauterine Response to Hypoxic Injury.
• The impact of ionizing radiation on placental trophoblasts.
• Advancing research transdisciplinarity within our discipline.
• Review: Placenta-specific microRNAs in exosomes - Good things come in nano-packages.
• Autophagy as a mechanism of antiviral defense at the maternal-fetal interface.
• Lipid raft- and SRC family kinase-dependent entry of coxsackievirus B into human placental trophoblasts.
• Human placental trophoblasts confer viral resistance to recipient cells.
• The role of trophoblastic microRNAs in placental viral infection.
• The expression and localization of N-myc downstream-regulated gene 1 in human trophoblasts.
• The Unique Expression and Function of miR-424 in Human Placental Trophoblasts.
• IFPA Meeting 2011 workshop report I: Placenta: Predicting future health; roles of lipids in the growth and development of feto-placental unit; placental nutrient sensi...
• IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; ...
• The expression and function of fatty acid transport protein-2 and -4 in the murine placenta.
• The timing and duration of hypoxia determine gene expression patterns in cultured human trophoblasts.
• Fatty Acid Binding Protein 4 Regulates Intracellular Lipid Accumulation in Human Trophoblasts.
• Expression patterns of placental microRNAs.
• Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.
• The levels of hypoxia-regulated microRNAs in plasma of pregnant women with fetal growth restriction.
• Administration of steroids after 34 weeks of gestation enhances fetal lung maturity profiles.
• Basic and clinical studies on functional RNA molecules for advanced medical technologies.
• Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort.
• MiR-205 silences MED1 in hypoxic primary human trophoblasts.
• Magnetic resonance imaging of hypoxic injury to the murine placenta.
• Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responses.
• The expression of connective tissue growth factor in pregnancies complicated by severe preeclampsia or fetal growth restriction.
• The C5b-9 membrane attack complex of complement activation localizes to villous trophoblast injury in vivo and modulates human trophoblast function in vitro.
• Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor.
• PPAR Signaling in Placental Development and Function.
• Epidermal growth factor abrogates hypoxia-induced apoptosis in cultured human trophoblasts through phosphorylation of BAD Serine 112.
• DEAD-box protein-103 (DP103, Ddx20) is essential for early embryonic development and modulates ovarian morphology and function.
• Hypoxia enhances the expression of follistatin-like 3 in term human trophoblasts.
• Endothelin-1 attenuates apoptosis in cultured trophoblasts from term human placentas.
• Hypoxia regulates the expression of fatty acid-binding proteins in primary term human trophoblasts.
• Ligand-activated peroxisome proliferator activated receptor gamma alters placental morphology and placental fatty acid uptake in mice.
• The expression of Argonaute2 and related microRNA biogenesis proteins in normal and hypoxic trophoblasts.
• Fetal heart rate accelerations and the risk of cerebral lesions and poor neurodevelopmental outcome in very low birthweight neonates.
• Increased expression of N-myc downstream-regulated gene 1 (NDRG1) in placentas from pregnancies complicated by intrauterine growth restriction or preeclampsia.
• Hypoxia regulates the expression of PHLDA2 in primary term human trophoblasts.
• The use of needle biopsy for assessment of placental gene expression.
• The pleiotropic function of PPAR gamma in the placenta.
• Advanced techniques in placental biology -- workshop report.
• The rare occurrence of absent adrenals in a term infant: a case report and review of the literature.
• Enhanced basal apoptosis in cultured term human cytotrophoblasts is associated with a higher expression and physical interaction of p53 and Bak.
• The kinase p38 regulates peroxisome proliferator activated receptor-gamma in human trophoblasts.
• Imprinting of PEG1/MEST isoform 2 in human placenta.
• N-myc down-regulated gene 1 modulates the response of term human trophoblasts to hypoxic injury.
• Insulin and fatty acids regulate the expression of the fat droplet-associated protein adipophilin in primary human trophoblasts.
• The mean weekly increment of amniotic fluid TDx-FLM II ratio is constant during the latter part of pregnancy.
• Microarray analysis of trophoblast cells.
• Fibrin enhances differentiation, but not apoptosis, and limits hypoxic injury of cultured term human trophoblasts.
• Tumor heterogeneity affects the precision of microarray analysis.
• The correlation between sampling site and gene expression in the term human placenta.
• Application of pregnancy-related proteins in prenatal and tumor diagnostics--a workshop report.
• Peroxisome proliferator-activated receptor-gamma and retinoid X receptor signaling regulate fatty acid uptake by primary human placental trophoblasts.
• Microarray-based identification of differentially expressed genes in hypoxic term human trophoblasts and in placental villi of pregnancies with growth restricted fetuses.
• Troglitazone attenuates hypoxia-induced injury in cultured term human trophoblasts.
• National Institute on Drug Abuse Conference report on placental proteins, drug transport, and fetal development.
• Homocysteine thiolactone induces apoptosis in cultured human trophoblasts: a mechanism for homocysteine-mediated placental dysfunction?
• Insulin enhances the transcription of luteinizing hormone-beta gene.
• Is hypotonic dysfunctional labor associated with hypophosphatemia?
• Increased measurement accuracy for sequence-verified microarray probes.
• Myocytes of chorionic vessels from placentas with meconium-associated vascular necrosis exhibit apoptotic markers.
• p300 regulates the synergy of steroidogenic factor-1 and early growth response-1 in activating luteinizing hormone-beta subunit gene.
• The lipid droplet-associated protein adipophilin is expressed in human trophoblasts and is regulated by peroxisomal proliferator-activated receptor-gamma/retinoid X re...
• Incorporation of gene-specific variability improves expression analysis using high-density DNA microarrays.
• Microarray analysis of uterine gene expression in mouse and human pregnancy.
• Human placenta metabolizes fatty acids: implications for fetal fatty acid oxidation disorders and maternal liver diseases.
• A novel domain within the DEAD-box protein DP103 is essential for transcriptional repression and helicase activity.
• A variable fold change threshold determines significance for expression microarrays.
• Hypoxia reduces expression and function of system A amino acid transporters in cultured term human trophoblasts.
• A prospective randomized safety trial of celecoxib for treatment of preterm labor.
• Trophoblast differentiation modulates the activity of caspases in primary cultures of term human trophoblasts.
• Trophoblast apoptosis from pregnancies complicated by fetal growth restriction is associated with enhanced p53 expression.
• Assessment of the diagnostic accuracy of the TDx-FLM II to predict fetal lung maturity.
• The activity of PPAR gamma in primary human trophoblasts is enhanced by oxidized lipids.
• Thromboxane A(2) limits differentiation and enhances apoptosis of cultured human trophoblasts.
• Estrogen modulates estrogen receptor alpha and beta expression, osteogenic activity, and apoptosis in mesenchymal stem cells (MSCs) of osteoporotic mice.
• Steroidogenic factor 1 is a monomeric orphan, but does not work alone.
• Enhancement of amniotic cyclooxygenase type 2 activity in women with preterm delivery associated with twins or polyhydramnios.
• The DEAD box protein DP103 is a regulator of steroidogenic factor-1.
• Peroxisome proliferator-activated receptor-gamma modulates differentiation of human trophoblast in a ligand-specific manner.
• Function of steroidogenic factor 1 during development and differentiation of the reproductive system.
• Inhibition of cyclooxygenase-2 prevents inflammation-mediated preterm labor in the mouse.
• Apoptosis in human cultured trophoblasts is enhanced by hypoxia and diminished by epidermal growth factor.
• Effective diminution of amniotic prostaglandin production by selective inhibitors of cyclooxygenase type 2.
• Steroidogenic factor-1 (SF-1), a specific transcriptional factor of differentiation and function of steroidogenic cells.
• Activation of luteinizing hormone beta gene by gonadotropin-releasing hormone requires the synergy of early growth response-1 and steroidogenic factor-1.

Schools

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• The Hebrew University Hadassah Medical School

• Barnes Jewish Hospital

Doctors Specialties

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• Maternal-Fetal Medicine
• Obstetrics
• Gynecology

Accepted Insurances

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Education

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• Washington University - Barnes-Jewish Hospital
• The Hebrew University of Jerusalem Hadassah Medical School

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