Professor, Pathology, University of Pittsburgh School of Medicine
Pathology
Dr. Yuri E. Nikiforov, MD
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Dr. Yuri E. Nikiforov is an expert in the field of Pathology. He went to University Hospital - University of Cincinnati College of Medicine. He over the years received 1 awards: "Elected Member". Yuri E. Nikiforov is a published doctor and has 99 publications published. The lastest was: 'A Multiplexed Amplicon Approach for Detecting Gene Fusions by Next-Generation Sequencing.' He is registered with Medicare and accepts Medicare payments.
Publications
- Targeted Next-Generation Sequencing Analysis of a Pendred Syndrome-Associated Thyroid Carcinoma.
- Targeted next-generation sequencing panel (GlioSeq) provides comprehensive genetic profiling of central nervous system tumors.
- A Multiplexed Amplicon Approach for Detecting Gene Fusions by Next-Generation Sequencing.
- Histopathologic and Clinical Characterization of Thyroid Tumors Carrying the BRAF(K601E) Mutation.
- Impact of the Multi-Gene ThyroSeq Next-Generation Sequencing Assay on Cancer Diagnosis in Thyroid Nodules with Atypia of Undetermined Significance/Follicular Lesion of...
- Can Malignant Thyroid Nodules Be Distinguished from Benign Thyroid Nodules in Children and Adolescents by Clinical Characteristics? A Review of 89 Pediatric Patients w...
- Thyroid nodules with KRAS mutations are different from nodules with NRAS and HRAS mutations with regard to cytopathologic and histopathologic outcome characteristics.
- Molecular approaches to thyroid cancer diagnosis.
- Highly accurate diagnosis of cancer in thyroid nodules with follicular neoplasm/suspicious for a follicular neoplasm cytology by ThyroSeq v2 next-generation sequencing...
- PAX8/PPARγ Rearrangement in Thyroid Nodules Predicts Follicular-Pattern Carcinomas, in Particular the Encapsulated Follicular Variant of Papillary Carcinoma.
- SeqReporter: Automating Next-Generation Sequencing Result Interpretation and Reporting Workflow in a Clinical Laboratory.
- RET Rearrangements in Lung Adenocarcinoma and Radiation.
- ETV6-NTRK3 is a common chromosomal rearrangement in radiation-associated thyroid cancer.
- Targeted Next-Generation Sequencing Panel (ThyroSeq) for Detection of Mutations in Thyroid Cancer.
- The increase in thyroid cancer incidence during the last four decades is accompanied by a high frequency of BRAF mutations and a sharp increase in RAS mutations.
- Preoperative cytology with molecular analysis to help guide surgery for pediatric thyroid nodules.
- Use of molecular biomarkers in FNA specimens to personalize treatment for thyroid surgery.
- Thyroid Nodules (≥4 cm): Can Ultrasound and Cytology Reliably Exclude Cancer?
- "Colloid-Rich" follicular neoplasm/suspicious for follicular neoplasm thyroid fine-needle aspiration specimens: Cytologic, histologic, and molecular basis for consider...
- Pulmonary Langerhans cell histiocytosis: profiling of multifocal tumors using next-generation sequencing identifies concordant occurrence of BRAF V600E mutations.
- RAS Mutations in Thyroid FNA Specimens Are Highly Predictive of Predominantly Low-Risk Follicular-Pattern Cancers.
- New Strategies in Diagnosing Cancer in Thyroid Nodules: Impact of Molecular Markers.
- Ewing sarcoma of the thyroid: Report of 2 cases and review of the literature.
- Homologous chromosomes move and rapidly initiate contact at the sites of double-strand breaks in genes in G?-phase human cells.
- RET/PTC and PAX8/PPAR? chromosomal rearrangements in post-Chernobyl thyroid cancer and their association with iodine-131 radiation dose and other characteristics.
- Comprehensive microRNA expression profiling identifies novel markers in follicular variant of papillary thyroid carcinoma.
- Diagnosis and management of differentiated thyroid cancer using molecular biology.
- BRAF V600E mutation independently predicts central compartment lymph node metastasis in patients with papillary thyroid cancer.
- MicroRNA Expression Array Identifies Novel Diagnostic Markers for Conventional and Oncocytic Follicular Thyroid Carcinomas.
- Frequency of close positioning of chromosomal loci detected by FRET correlates with their participation in carcinogenic rearrangements in human cells.
- BRAF mutation detection in indeterminate thyroid cytology specimens: Underlying cytologic, molecular, and pathologic characteristics of papillary thyroid carcinoma.
- Formation of carcinogenic chromosomal rearrangements in human thyroid cells after induction of double-strand DNA breaks by restriction endonucleases.
- Cytomorphological and molecular genetic findings in pediatric thyroid fine-needle aspiration.
- Suspicious ultrasound characteristics predict BRAF V600E-positive papillary thyroid carcinoma.
- Cost impact of molecular testing for indeterminate thyroid nodule fine-needle aspiration biopsies.
- Suitability of animal models for studying radiation-induced thyroid cancer in humans: evidence from nuclear architecture.
- Impact of Mutational Testing on the Diagnosis and Management of Patients with Cytologically Indeterminate Thyroid Nodules: A Prospective Analysis of 1056 FNA Samples.
- A combined molecular-pathologic score improves risk stratification of thyroid papillary microcarcinoma.
- Molecular genetics and diagnosis of thyroid cancer.
- Molecular Analysis of Thyroid Tumors.
- MicroRNA Signature Distinguishes the Degree of Aggressiveness of Papillary Thyroid Carcinoma.
- Both BRAF V600E mutation and older age (≥ 65 years) are associated with recurrent papillary thyroid cancer.
- Molecular diagnostics of thyroid tumors.
- MicroRNA dysregulation in human thyroid cells following exposure to ionizing radiation.
- Summary statement: utility of molecular marker testing in thyroid cancer.
- Encapsulated papillary oncocytic neoplasms of the thyroid: morphologic, immunohistochemical, and molecular analysis of 18 cases.
- Neoadjuvant treatment of unresectable medullary thyroid cancer with sunitinib.
- Detection of IDH1 and IDH2 mutations by fluorescence melting curve analysis as a diagnostic tool for brain biopsies.
- RAS mutation-positive follicular variant of papillary thyroid carcinoma arising in a struma ovarii.
- Is ionizing radiation responsible for the increasing incidence of thyroid cancer?
- Contribution of molecular testing to thyroid fine-needle aspiration cytology of "follicular lesion of undetermined significance/atypia of undetermined significanc...
- Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumors.
- Optimizing surgical treatment of papillary thyroid carcinoma associated with BRAF mutation.
- Molecular diagnostics and predictors in thyroid cancer.
- RAS mutations are the predominant molecular alteration in poorly differentiated thyroid carcinomas and bear prognostic impact.
- Molecular testing for mutations in improving the fine-needle aspiration diagnosis of thyroid nodules.
- Knockdown of IG20 gene expression renders thyroid cancer cells susceptible to apoptosis.
- Gene position within chromosome territories correlates with their involvement in distinct rearrangement types in thyroid cancer cells.
- MicroRNA expression profiles in thyroid tumors.
- Tumor-to-tumor metastases to follicular variant of papillary thyroid carcinoma: histologic, immunohistochemical, and molecular studies of two unusual cases.
- Loss of heterozygosity of selected tumor suppressor genes in parathyroid carcinoma.
- Utilization of ancillary studies in thyroid fine needle aspirates: a synopsis of the National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conf...
- Thyroid carcinoma: molecular pathways and therapeutic targets.
- MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utility.
- Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach.
- RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis.
- Follicular variant papillary thyroid carcinoma arising within an ovarian teratoma.
- Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneity.
- Proliferative activity of human thyroid cells in various age groups and its correlation with the risk of thyroid cancer after radiation exposure.
- RET/PTC Rearrangement--a link between Hashimoto's thyroiditis and thyroid cancer...or not.
- Delineation, functional validation, and bioinformatic evaluation of gene expression in thyroid follicular carcinomas with the PAX8-PPARG translocation.
- Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas.
- Radiation-induced thyroid cancer: what we have learned from chernobyl.
- Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation.
- Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: a model of carcinogenic chromosomal rearrangement induced by io...
- BRAF kinase activation via chromosomal rearrangement in radiation-induced and sporadic thyroid cancer.
- Detection of SYT-SSX rearrangements in synovial sarcomas by real-time one-step RT-PCR.
- Editorial: anaplastic carcinoma of the thyroid--will aurora B light a path for treatment?
- BRAF copy number gains in thyroid tumors detected by fluorescence in situ hybridization.
- Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer.
- Alterations of the BRAF gene in thyroid tumors.
- Analysis of BRAF point mutation and RET/PTC rearrangement refines the fine-needle aspiration diagnosis of papillary thyroid carcinoma.
- Amiodarone-induced thyrotoxicosis and thyroid cancer: clinical, immunohistochemical, and molecular genetic studies of a case and review of the literature.
- Multiple focal nodular hyperplasia of the liver in a 21-year-old woman.
- Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells.
- Genetic alterations involved in the transition from well-differentiated to poorly differentiated and anaplastic thyroid carcinomas.
- The molecular pathways induced by radiation and leading to thyroid carcinogenesis.
- BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas.
- Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations.
- RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma.
- High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcin...
- PAX8-PPARgamma rearrangement in thyroid tumors: RT-PCR and immunohistochemical analyses.
- Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.
- Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement.
- Prevalence of RET/PTC rearrangements in Hashimoto's thyroiditis and papillary thyroid carcinomas.
- RET/PTC rearrangement in thyroid tumors.
- MicroRNA profile of poorly differentiated thyroid carcinomas: new diagnostic and prognostic insights.
- Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFβ signaling.
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
Awards
- Elected Member
Education
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University Hospital - University of Cincinnati College of Medicine -
Minsk Medical Institute
Hospital
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UPMC Passavant -
UPMC Presbyterian Shadyside
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1104851310 |
| Last Name Of The Provider | NIKIFOROV |
| First Name Of The Provider | YURI |
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