Professor of Medicine, University Fla College of Medicine
Infectious Disease
Dr. Frederick S. Southwick, MD
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Frederick S. Southwick practices Infectious Disease. He studied medicine at Columbia University College of Physicians & Surgeons. Columbia University College of Physicians & Surgeons is a top medical college. Columbia University College of Physicians & Surgeons is ranked 8/52 in Research/PrimaryCare. He received awards:"Advanced Leadership Fellow", "Whos Who in America", "Exemplary Teacher Award", "Theodore E. Woodward Award", "Elected Outstanding Division in the Department of Medicine", "Teaching Excellence Award", "Elected Fellow", "University of Florida Research Foundation Award for distinguished research accomplishments", "Maxwell Finland Lecturer", "Maxwell Finland Lecturer, Infectious Disease Society of America Annual Award", "Faculty Research Prize for Clinical Science", "Professors Excellence Award", "Fellow (FACP)", "Elected Member", "Dean's List", "International Fellow", "Edward J. Noble Foundation Leadership grant", "Muscular Dystrophy Research Fellowship Award", "National Research Service Award" and "Honorary Degree". Frederick Southwick is a published doctor as well. He has 88 publications published. The latest was: Vaccinia locomotion in host cells: evidence for the universal involvement of actin-based motility sequences ABM-1 and ABM-2. He is registered with Medicare and accepts Medicare payments.
Publications
- Applying athletic principles to medical rounds to improve teaching and patient care.
- Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread.
- Anthrax Lethal and Edema Toxins Fail to Directly Impair Human Platelet Function.
- Brucella, voles, and emerging pathogens.
- Commentary: "Who was caring for Mary?" revisited: a call for all academic physicians caring for patients to focus on systems and quality improvement.
- Bacillus anthracis edema toxin impairs neutrophil actin-based motility.
- Theodore E. Woodward Award: spare me the PowerPoint and bring back the medical textbook.
- Anthrax lethal toxin paralyzes neutrophil actin-based motility.
- CapG(-/-) mice have specific host defense defects that render them more susceptible than CapG(+/+) mice to Listeria monocytogenes infection but not to Salmonella enter...
- Depolymerization of actin filaments by profilin. Effects of profilin on capping protein function.
- Actin-based endosome and phagosome rocketing in macrophages: activation by the secretagogue antagonists lanthanum and zinc.
- Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts.
- A direct-transfer polymerization model explains how the multiple profilin-binding sites in the actoclampin motor promote rapid actin-based motility.
- Actin-based phagosome motility.
- The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.
- Platelet-activating factor both stimulates and "primes" human polymorphonuclear leukocyte actin filament assembly.
- Neutrophil actin dysfunction is a genetic disorder associated with partial impairment of neutrophil actin assembly in three family members.
- Contractile proteins in leukocytes.
- Recurrent cystitis and bladder mass in two adults with chronic granulomatous disease.
- Septic thrombosis of the dural venous sinuses.
- Effects of acridine orange on the growth of Escherichia coli.
- Chemotherapy of experimental streptococcal endocarditis. 3. Failure of a bacteriostatic agent (tetracycline) in prophylaxis.
- The development of sexual dimorphism in transplanted mouse pelves.
- An analogue of the erythroid membrane skeletal protein 4.1 in nonerythroid cells.
- A variant of chronic granulomatous disease: deficient oxidative metabolism due to a low-affinity NADPH oxidase.
- Acumentin, a protein in macrophages which caps the "pointed" end of action filaments.
- Contractile proteins in leukocyte function.
- Calcium regulation of actin filament capping and monomer binding by macrophage capping protein.
- Arrest of Listeria movement in host cells by a bacterial ActA analogue: implications for actin-based motility.
- Acute bacterial meningitis in adults. A review of 493 episodes.
- Diminished actin polymerization by neutrophils from newborn infants.
- Intracellular pathogenesis of listeriosis.
- Recognition of two classes of oligoproline sequences in profilin-mediated acceleration of actin-based Shigella motility.
- Purification and properties of a Ca(2+)-independent barbed-end actin filament capping protein, CapZ, from human polymorphonuclear leukocytes.
- ABM-1 and ABM-2 homology sequences: consensus docking sites for actin-based motility defined by oligoproline regions in Listeria ActA surface protein and human VASP.
- Profilin interacts with the Gly-Pro-Pro-Pro-Pro-Pro sequences of vasodilator-stimulated phosphoprotein (VASP): implications for actin-based Listeria motility.
- Vinculin proteolysis unmasks an ActA homolog for actin-based Shigella motility.
- Listeria and Shigella actin-based motility in host cells.
- Gelsolin, a protein that caps the barbed ends and severs actin filaments, enhances the actin-based motility of Listeria monocytogenes in host cells.
- Vaccinia locomotion in host cells: evidence for the universal involvement of actin-based motility sequences ABM-1 and ABM-2.
- Actin-based motility of the intracellular pathogen Listeria monocytogenes: assessing the inhibitory specificity of ABM-1 peptide analogues.
- Energetics of nucleotide hydrolysis in polymer assembly/disassembly: the cases of actin and tubulin.
- Profilin promotes barbed-end actin filament assembly without lowering the critical concentration.
- Shigella actin-based motility in the presence of truncated vinculin.
- Gelsolin and ADF/cofilin enhance the actin dynamics of motile cells.
- Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing.
- Phosphoinositide 3-kinase is required for intracellular Listeria monocytogenes actin-based motility and filopod formation.
- Gelsolin mediates calcium-dependent disassembly of Listeria actin tails.
- Methicillin-resistant Staphylococcus aureus infection in a college football team: risk factors outside the locker room and playing field.
- Commentary: IDSA guidelines for improving the teaching of preclinical medical microbiology and infectious diseases.
- The potential influence of common viral infections diagnosed during hospitalization among critically ill patients in the United States.
- Who was caring for Mary?
- N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.
- Who was caring for Mary? 1993.
- Sphenoid sinusitis.
- Exserohilum rostratum: Characterization of a Cross-Kingdom Pathogen of Plants and Humans.
- A CapG gain-of-function mutant reveals critical structural and functional determinants for actin filament severing.
- Anthrax lethal toxin paralyzes actin-based motility by blocking Hsp27 phosphorylation.
- The motor of leukocytes.
- Sphenoid sinusitis. A review of 30 cases.
- Isolation of an inhibitor of actin polymerization from human polymorphonuclear leukocytes.
- Hemophilus influenzae in hospitalized adults: current perspectives.
- Recovery after prolonged asystolic cardiac arrest in profound hypothermia. A case report and literature review.
- Acumentin, an actin-modulating protein of rabbit pulmonary macrophages.
- An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein.
- Septic thrombophlebitis of major dural venous sinuses.
- Listeria monocytogenes intracellular migration: inhibition by profilin, vitamin D-binding protein and DNase I.
- Inhibition of Listeria locomotion by mosquito oostatic factor, a natural oligoproline peptide uncoupler of profilin action.
- Gain-of-function mutations conferring actin-severing activity to human macrophage cap G.
- Dynamic remodeling of the actin cytoskeleton: lessons learned from Listeria locomotion.
- The human actin-regulatory protein cap G: gene structure and chromosome location.
- Defective leukocyte metabolism.
- Cardiac risk factors and complications in non-cardiac surgery.
- Multifactorial index of cardiac risk in noncardiac surgical procedures.
- Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages.
- Host cell actin assembly is necessary and likely to provide the propulsive force for intracellular movement of Listeria monocytogenes.
- Stimulation of human polymorphonuclear leukocyte phosphatidylinositol-4-phosphate kinase by concanavalin A and formyl-methionyl-leucyl-phenylalanine is calcium-indepen...
- Binding of IgG containing immune complexes to human neutrophil Fc gamma RII and Fc gamma RIII induces actin polymerization by a pertussis toxin-insensitive transductio...
- Listeria monocytogenes moves rapidly through the host-cell cytoplasm by inducing directional actin assembly.
- Septic cortical thrombophlebitis.
- Kinetics of the interaction of a 41-kilodalton macrophage capping protein with actin: promotion of nucleation during prolongation of the lag period.
- The actin released from profilin--actin complexes is insufficient to account for the increase in F-actin in chemoattractant-stimulated polymorphonuclear leukocytes.
- Polymorphonuclear leukocyte adherence induces actin polymerization by a transduction pathway which differs from that used by chemoattractants.
- The relationship between CR3 deficiency and neutrophil actin assembly.
- Effects of macrophage profilin on actin in the presence and absence of acumentin and gelsolin.
- Rabbit alveolar macrophages contain a Ca2+-sensitive, 41,000-dalton protein which reversibly blocks the "barbed" ends of actin filaments but does not sever them.
- Nonmuscle actin-binding proteins.
Schools
Columbia University College of Physicians And Surgeons
Boston City Hospital
Massachusetts General Hospital
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Awards
- Advanced Leadership Fellow
- Who’s Who in America
- Exemplary Teacher Award
- Theodore E. Woodward Award
- Elected Outstanding Division in the Department of Medicine
- Teaching Excellence Award
- Elected Fellow
- University of Florida Research Foundation Award for distinguished research accomplishments
- Maxwell Finland Lecturer
- Maxwell Finland Lecturer, Infectious Disease Society of America Annual Award
- Faculty Research Prize for Clinical Science
- Professors’ Excellence Award
- Fellow (FACP)
- Elected Member
- Dean's List
- International Fellow
- Edward J. Noble Foundation Leadership grant
- Muscular Dystrophy Research Fellowship Award
- National Research Service Award
- Honorary Degree
Education
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Massachusetts General Hospital -
Boston University Medical Center -
Columbia University College of Physicians & Surgeons -
Yale University
Hospital
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UF Health Shands Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1851328520 |
| Last Name Of The Provider | SOUTHWICK |
| First Name Of The Provider | FREDERICK |
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