Professor, Neurology, Baylor College of Medicine

Neurology

Dr. Jeffrey L. Noebels, MD

Jeffrey L. Noebels practices Neurology. Jeffrey Noebels is also published. He has 101 publications published. The lastest publication: "Increased excitability and inward rectification in layer V cortical pyramidal neurons in the epileptic mutant mouse Stargazer.'

Publications

Sudden unexpected death in epilepsy: Identifying risk and preventing mortality.
Early rescue of interneuron disease trajectory in developmental epilepsies.
Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Pur...
Hyper-SUMOylation of the Kv7 Potassium Channel Diminishes the M-Current Leading to Seizures and Sudden Death.
Bexarotene reduces network excitability in models of Alzheimer's disease and epilepsy.
Neonatal estradiol stimulation prevents epilepsy in arx model of x-linked infantile spasms syndrome.
Issues related to development of new antiseizure treatments.
Novel brain expression of ClC-1 chloride channels and enrichment of CLCN1 variants in epilepsy.
Visual Automated Fluorescence Electrophoresis Provides Simultaneous Quality, Quantity, and Molecular Weight Spectra for Genomic DNA from Archived Neonatal Blood Spots.
Postnatal loss of p/q-type channels confined to rhombic-lip-derived neurons alters synaptic transmission at the parallel fiber to purkinje cell synapse and replicates ...
Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy.
Interneuron, interrupted: molecular pathogenesis of ARX mutations and X-linked infantile spasms.
Comparative Analytical Utility of DNA Derived from Alternative Human Specimens for Molecular Autopsy and Diagnostics.
Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-?-Mediated Disinhibition.
To share or not to share: A randomized trial of consent for data sharing in genome research.
MeCP2 Is Critical within HoxB1-Derived Tissues of Mice for Normal Lifespan.
Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations.
Amyloid-ÃŽÂ²/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.
Knockout of Zn transporters Zip-1 and Zip-3 attenuates seizure-induced CA1 neurodegeneration.
"Jasper's Basic Mechanisms of the Epilepsies" Workshop.
Arc regulates spine morphology and maintains network stability in vivo.
Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy.
Genetic testing in the epilepsies--report of the ILAE Genetics Commission.
A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult co...
Sodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion.
Curing epilepsy: progress and future directions.
Genetic enhancement of thalamocortical network activity by elevating alpha 1g-mediated low-voltage-activated calcium current induces pure absence epilepsy.
Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3.
2006 Merritt Putnam Symposium: mapping epileptic circuitry.
Masking epilepsy by combining two epilepsy genes.
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.
The Judith Hoyer Lecture: genes, pixels, patterns, and prevention.
Exocytosis of vesicular zinc reveals persistent depression of neurotransmitter release during metabotropic glutamate receptor long-term depression at the hippocampal C...
BK channel beta4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures.
Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy.
Calcium channel "gaiting" and absence epilepsy.
Genetic mouse models of essential tremor: are they essential?
Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice.
Elevated thalamic low-voltage-activated currents precede the onset of absence epilepsy in the SNAP25-deficient mouse mutant coloboma.
Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture.
Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1).
Stiff Goats, Chloride Ions, and Idiopathic Generalized Epilepsy (IGE).
Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) contiguous gene syndromes by chromosome engineering in mice: phenotypic consequences of gene dosage imbalance.
Genetic and phenotypic analysis of the mouse mutant mh2J, an Ap3d allele caused by IAP element insertion.
How a Sodium Channel Mutation Causes Epilepsy.
Genetic disruption of cortical interneuron development causes region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction.
Exploring new gene discoveries in idiopathic generalized epilepsy.
The biology of epilepsy genes.
Models for epilepsy and epileptogenesis: report from the NIH workshop, Bethesda, Maryland.
Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons.
A Gene for JME at Last: The alpha1 GABA Receptor Subunit.
Human Epilepsy Can Be Linked to a Defective Calcium Channel.
Ion Channelopathies and Heritable Epilepsy.
Single-Gene Determinants of Epilepsy Comorbidity.
Monogenic models of absence epilepsy: windows into the complex balance between inhibition and excitation in thalamocortical microcircuits.
Paradoxical proepileptic response to NMDA receptor blockade linked to cortical interneuron defect in stargazer mice.
Increased excitability and inward rectification in layer V cortical pyramidal neurons in the epileptic mutant mouse Stargazer.
Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse.
Neurogenetic approaches to axon sprouting in the hippocampus.
Hypomyelination alters K+ channel expression in mouse mutants shiverer and Trembler.
Targeting epilepsy genes.
Glutamate transporter mRNA expression in proliferative zones of the developing and adult murine CNS.
Selective failure of brain-derived neurotrophic factor mRNA expression in the cerebellum of stargazer, a mutant mouse with ataxia.
Genetic mapping and evaluation of candidate genes for spasmodic, a neurological mouse mutation with abnormal startle response.
Localization and modulatory actions of zinc in vertebrate retina.
Developmental analysis of hippocampal mossy fiber outgrowth in a mutant mouse with inherited spike-wave seizures.
Analysis of voltage-gated and synaptic conductances contributing to network excitability defects in the mutant mouse tottering.
Genetic epilepsy model derived from common inbred mouse strains.
Single locus mutations in mice expressing generalized spike-wave absence epilepsies.
Molecular characterization of a high-affinity mouse glutamate transporter.
Aberrant expression of neuropeptide Y in hippocampal mossy fibers in the absence of local cell injury following the onset of spike-wave synchronization.
Mutant mouse tottering: selective increase of locus ceruleus axons in a defined single-locus mutation.
A single gene error of noradrenergic axon growth synchronizes central neurones.
Isolating single genes of the inherited epilepsies.
Mutational analysis of inherited epilepsies.
Persistent hypersynchronization of neocortical neurons in the mocha mutant of mouse.
Altered hippocampal network excitability in the hypernoradrenergic mutant mouse tottering.
Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures.
Synchronous hippocampal bursting reveals network excitability defects in an epilepsy gene mutation.
Genetic and phenotypic heterogeneity of inherited spike-wave epilepsy: two mutant gene loci with independent cerebral excitability defects.
Mutational analysis of spike-wave epilepsy phenotypes.
Sodium channel density in hypomyelinated brain increased by myelin basic protein gene deletion.
A burst-dependent hippocampal excitability defect elicited by potassium at the developmental onset of spike-wave seizures in the Tottering mutant.
Elevated expression of type II Na+ channels in hypomyelinated axons of shiverer mouse brain.
Transcallosal effects of a cortical epileptiform focus.
Development of focal seizures in cerebral cortex: role of axon terminal bursting.
Cortical slow potentials and the occipital EEG in congenital blindness.
Inherited epilepsy: spike-wave and focal motor seizures in the mutant mouse tottering.
Anatomic localization of topically applied [14C]penicillin during experimental focal epilepsy in cat neocortex.
Analysis of inherited epilepsy using single locus mutations in mice.
Excitability changes in thalamocortical relay neurons during synchronous discharges in cat neocortex.
Presynaptic origin of penicillin after discharges at mammalian nerve terminals.
Expression of apoptosis inhibitor protein Mcl1 linked to neuroprotection in CNS neurons.
Apoptosis caused by cathepsins does not require Bid signaling in an in vivo model of progressive myoclonus epilepsy (EPM1).
Future directions for epilepsy research.
Loss of the potassium channel beta-subunit gene, KCNAB2, is associated with epilepsy in patients with 1p36 deletion syndrome.
Males with epilepsy, complete subcortical band heterotopia, and somatic mosaicism for DCX.
Modeling human epilepsies in mice.
Presynaptic Ca2+ channels and neurotransmitter release at the terminal of a mouse cortical neuron.
Absence of hippocampal mossy fiber sprouting in transgenic mice overexpressing brain-derived neurotrophic factor.

Schools

Yale University

Doctors Specialties

Neurology

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