Professor, Pediatrics, University of Minnesota Medical School
Pediatric Hematology & Oncology
Dr. Jakub Tolar, MD
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Jakub Tolar practices Pediatric Hematology & Oncology. He has 19 awards "Regional Top Doctor", "Innovator in Translational Research Award, Pediatric Faculty Recognition", "Leadership in Healthcare, Change Agent Award", "Rare Disease Research Hall of Fame", "CMS Meaningful Use Stage 1 Certification", "Who is your Superhero?", "Super Doctors", "Top Doctors Minneapolis", "Butterfly Award, Childrens Cancer Research Fund", "Scientist Development Award", "University Pediatrics Foundation Scholar", "Young Investigator Award", "Margaret Kendrick Hostetter MD Award for Research in Pediatric Subspecialty Training (1st Place, the 17th Annual Pediatric Research, Education and Scholarship Symposium)", "Masonic Dietz Family Award for Travel", "5K12HD33692-07 Child Health Research Scholar", "Bone Marrow Transplantation Award", "Travel Award for Abstract Presentation", "Academic Achievement Award of the Chancellor" and "Super Doctor". Jakub Tolar is also published. He has 40 publications published. The lastest publication: "Venturing into the New Science ofNucleases.'
Publications
- Gene editing toward the use of autologous therapies in recessive dystrophic epidermolysis bullosa.
- IL-15 Trispecific Killer Engagers (TriKEs) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing In Vivo Expansion, and Enhanced Function.
- Mesenchymal stromal cells inhibit murine syngeneic anti-tumor immune responses by attenuating inflammation and reorganizing the tumor microenvironment.
- Evaluation of TCR Gene Editing achieved by TALENs, CRISPR/Cas9 and megaTAL nucleases.
- GSK3β inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells.
- GvHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells.
- Placenta-based therapies for the treatment of epidermolysis bullosa.
- Fanconi Anemia Gene Editing by the CRISPR/Cas9 System.
- Derivation and High Engraftment of Patient-Specific Cardiomyocyte-Sheet Using Induced Pluripotent Stem Cells Generated From Adult Cardiac Fibroblast.
- Incidence of intracranial germ cell tumors by race in the United States, 1992-2010.
- The individual (single patient) IND for inborn errors of metabolism.
- An exploratory analysis of mitochondrial haplotypes and allogeneic hematopoietic cell transplantation (HCT) outcomes.
- sdf1 expression reveals a source of perivascular-derived mesenchymal stem cells in zebrafish.
- From marrow to matrix: novel gene and cell therapies for epidermolysis bullosa.
- On Medawar's 'Actively acquired tolerance of foreign cells'.
- Patient-Specific Naturally Gene-Reverted Induced Pluripotent Stem Cells in Recessive Dystrophic Epidermolysis Bullosa.
- Allogeneic blood and bone marrow cells for the treatment of severe epidermolysis bullosa: repair of the extracellular matrix.
- Hip Dysplasia in Patients With Hurler Syndrome (Mucopolysaccharidosis Type 1H).
- DNA methylation of Runx1 regulatory regions correlates with transition from primitive to definitive hematopoietic potential in vitro and in vivo.
- Outcomes of allogeneic hematopoietic cell transplantation in patients with dyskeratosis congenita.
- Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration.
- TALEN-based Gene Correction for Epidermolysis Bullosa.
- Bone Marrow Stromal and Vascular Smooth Muscle Cells Have Chemosensory Capacity via Bitter Taste Receptor Expression.
- Pericardial effusion after pediatric hematopoietic cell transplant.
- Translating genome engineering to better clinical outcomes.
- Enzyme Replacement is Associated with Better Cognitive Outcomes after Transplant in Hurler Syndrome.
- Cardiac Ultrasound Findings in Infants with Severe (Hurler Phenotype) Untreated Mucopolysaccharidosis (MPS) Type I.
- Management of severe epidermolysis bullosa by haematopoietic transplant: principles, perspectives and pitfalls.
- Cerebrospinal fluid matrix metalloproteinases are elevated in cerebral adrenoleukodystrophy and correlate with MRI severity and neurologic dysfunction.
- Keratinocytes from Induced Pluripotent Stem Cells in Junctional Epidermolysis Bullosa.
- Childhood cerebral X-linked adrenoleukodystrophy: diffusion tensor imaging measurements for prediction of clinical outcome after hematopoietic stem cell transplantation.
- An exploratory study of brain function and structure in mucopolysaccharidosis type I: Long term observations following hematopoietic cell transplantation (HCT).
- Fludarabine-based Conditioning for Marrow Transplantation from Unrelated Donors in Severe Aplastic Anemia: Early Results of a Cyclophosphamide Dose De-escalation Study...
- Reinventing mesenchymal stromal cells.
- Amelioration of epidermolysis bullosa by transfer of wild-type bone marrow cells.
- Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology.
- MSC Therapy Attenuates Obliterative Bronchiolitis after Murine Bone Marrow Transplant.
- Advances in understanding and treating dystrophic epidermolysis bullosa.
- Venturing into the New Science of Nucleases.
Conditions Treated
- Anemia
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Awards
- Regional Top Doctor
- Innovator in Translational Research Award, Pediatric Faculty Recognition
- Leadership in Healthcare, “Change Agent†Award
- Rare Disease Research Hall of Fame
- CMS Meaningful Use Stage 1 Certification
- Who is your Superhero?
- Super Doctors
- Top Doctors Minneapolis
- Butterfly Award, Children’s Cancer Research Fund
- Scientist Development Award
- University Pediatrics Foundation Scholar
- Young Investigator Award
- Margaret Kendrick Hostetter MD Award for Research in Pediatric Subspecialty Training (1st Place, the 17th Annual Pediatric Research, Education and Scholarship Symposium)
- Masonic Dietz Family Award for Travel
- 5K12HD33692-07 Child Health Research Scholar
- Bone Marrow Transplantation Award
- Travel Award for Abstract Presentation
- Academic Achievement Award of the Chancellor
- Super Doctor
Education
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University of Minnesota -
Karlovy University Faculty of Medicine
Hospital
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University of Minnesota Medical Center, Fairview
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