Paul J. Orchard, MD Professor, Division of Pediatric Bone Marrow Transplantation University of Minnesota
Pediatric Hematology & Oncology
Dr. Paul J. Orchard, MD
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Paul Orchard is an expert in the field of Pediatric Hematology & Oncology. He researched medicine at Warren Alpert Medical School of Brown University. He has 3 awards "Regional Top Doctor", "CMS Meaningful Use Stage 1 Certification" and "Super Doctor". Paul Orchard is a published doctor as well. He has 100 publications published. The latest was: Hematopoietic stem cell transplantation for infantile osteopetrosis.
Publications
- Indications for Autologous and Allogeneic Hematopoietic Cell Transplantation: Guidelines from the American Society for Blood and Marrow Transplantation.
- Outcomes after Hematopoietic Stem Cell Transplant for Children with I-Cell Disease.
- Unexpected coronary artery findings in mucopolysaccharidosis. Report of four cases and literature review.
- Effect of recombinant human growth hormone on changes in height, bone mineral density, and body composition over 1-2years in children with Hurler or Hunter syndrome.
- Prospects for stem cell therapy in neuronal ceroid lipofuscinosis.
- Hip Dysplasia in Patients With Hurler Syndrome (Mucopolysaccharidosis Type 1H).
- Low Bone Mineral Content and Challenges in Interpretation of Dual-Energy X-Ray Absorptiometry in Children With Mucopolysaccharidosis Types I, II, and VI.
- Pericardial effusion after pediatric hematopoietic cell transplant.
- Cardiac Ultrasound Findings in Infants with Severe (Hurler Phenotype) Untreated Mucopolysaccharidosis (MPS) Type I.
- Enzyme Replacement is Associated with Better Cognitive Outcomes after Transplant in Hurler Syndrome.
- Multi-institutional assessments of transplantation for metabolic Disorders.
- Cerebrospinal fluid matrix metalloproteinases are elevated in cerebral adrenoleukodystrophy and correlate with MRI severity and neurologic dysfunction.
- Interaction of n-acetylcysteine and cysteine in human plasma.
- Childhood cerebral X-linked adrenoleukodystrophy: diffusion tensor imaging measurements for prediction of clinical outcome after hematopoietic stem cell transplantation.
- An exploratory study of brain function and structure in mucopolysaccharidosis type I: Long term observations following hematopoietic cell transplantation (HCT).
- Population Pharmacokinetics of Unbound Mycophenolic Acid in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplantation.
- Chitotriosidase as a biomarker of cerebral adrenoleukodystrophy.
- Outcomes following allogeneic hematopoietic cell transplantation for childhood cerebral adrenoleukodystrophy: the largest single-institution cohort report.
- Analysis of Glycosaminoglycans in Cerebrospinal Fluid from Patients with Mucopolysaccharidoses by Isotope-Dilution Ultra-Performance Liquid Chromatography/Tandem Mass ...
- Leukodystrophy and gene therapy with a dimmer switch.
- Clinical outcomes following hematopoietic stem cell transplantation for the treatment of mucopolysaccharidosis VI.
- Outcome of penetrating keratoplasty for mucopolysaccharidoses.
- Early diagnosis of cerebral X-linked adrenoleukodystrophy in boys with Addison''s Disease improves survival and neurological outcomes.
- Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome).
- Acid sphingomyelinase deficiency does not protect from Graft-versus-host disease in transplant recipients with Niemann-Pick disease.
- Costs of pediatric allogeneic hematopoietic-cell transplantation.
- Transplant outcomes in leukodystrophies.
- Dyskeratosis congenita: the first NIH clinical research workshop.
- Osteopetrosis with micro-lacunar resorption because of defective integrin organization.
- Myeloablative hematopoietic cell transplantation for Acute lymphoblastic leukemia: analysis of graft sources and long-term outcome.
- Glutathione S-transferase A1 genetic variants reduce busulfan clearance in children undergoing hematopoietic cell transplantation.
- Allogeneic hematopoietic cell transplantation in children with relapsed Acute lymphoblastic leukemia isolated to the central nervous system.
- Higher mycophenolate dose requirements in children undergoing hematopoietic cell transplant (HCT).
- Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malaria.
- Hematopoietic cell therapy for metabolic Disease.
- Long-term results of autologous stem cell transplantation for primary refractory or relapsed Hodgkin's lymphoma.
- Coexpression of the uracil phosphoribosyltransferase gene with a chimeric human nerve growth factor receptor/cytosine deaminase fusion gene, using a single retroviral ...
- Inflammatory cytokines and the development of pulmonary complications after allogeneic hematopoietic cell transplantation in patients with inherited metabolic storage ...
- Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system.
- The Minnesota Molecular and Cellular Therapeutics Facility: a state-of-the-art biotherapeutics engineering laboratory.
- Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer.
- Long-term follow-up after autologous hematopoietic stem cell transplantation for low-grade non-Hodgkin lymphoma.
- Cerebral X-linked adrenoleukodystrophy: the international hematopoietic cell transplantation experience from 1982 to 1999.
- In vitro differentiation of CD14 cells from osteopetrotic subjects: contrasting phenotypes with TCIRG1, CLCN7, and attachment defects.
- Effective treatment of alpha-mannosidosis by allogeneic hematopoietic stem cell transplantation.
- Chloride channel ClCN7 mutations are responsible for severe recessive, dominant, and intermediate osteopetrosis.
- Human nerve growth factor receptor and cytosine deaminase fusion genes.
- Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant Diseases: influence of CD34 cell dose and HLA disparity on trea...
- Clinical-scale selection of anti-CD3/CD28-activated T cells after transduction with a retroviral vector expressing herpes simplex virus thymidine kinase and truncated ...
- Research challenges in central nervous system manifestations of inborn errors of metabolism.
- Clinical importance of pre-morteum blood lymphocytes in cadaver donor tissue typing.
- Primary hepatic lymphoma in an adolescent treated with hepatic lobectomy and chemotherapy.
- Primary nonfunction and preformed anti-HLA antibodies.
- Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta.
- Continued neurocognitive development and prevention of cardiopulmonary complications after successful BMT for I-cell Disease: a long-term follow-up report.
- Report of severe neurotoxicity with cyclophosphamide.
- The mutational spectrum of human malignant autosomal recessive osteopetrosis.
- EnGraftment and survival following hematopoietic stem cell transplantation for osteopetrosis using a reduced intensity conditioning regimen.
- Central pontine myelinolysis following bone marrow transplantation complicated by severe hepatic veno-occlusive Disease.
- Molecular and clinical heterogeneity in CLCN7-dependent osteopetrosis: report of 20 novel mutations.
- Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations.
- TCIRG1-dependent recessive osteopetrosis: mutation analysis, functional identification of the splicing defects, and in vitro rescue by U1 snRNA.
- Direct and bystander killing of sarcomas by novel cytosine deaminase fusion gene.
- Pharmacokinetics of clofarabine in patients with high-risk inherited metabolic Disorders undergoing brain-sparing hematopoietic cell transplantation.
- Disease-specific hematopoietic cell transplantation: nonmyeloablative conditioning regimen for dyskeratosis congenita.
- Lower Leukemia relapse in pediatric patients with pulmonary cytolytic thrombi following allogeneic transplant.
- Hematopoietic stem cell transplantation for infantile osteopetrosis.
- Haemopoietic cell transplantation in children with juvenile myelomonocytic leukaemia.
- Graft-versus-Leukemia is sufficient to induce remission in juvenile myelomonocytic Leukemia.
- Endogenous IL-2 production by natural killer cells maintains cytotoxic and proliferative capacity following retroviral-mediated gene transfer.
- The role of B7 costimulation by murine Acute myeloid leukemia in the generation and function of a CD8+ T-cell line with potent in vivo graft-versus-leukemia properties.
- Unrelated donor bone marrow transplantation for children and adolescents with aplastic anaemia or myelodysplasia.
- Unrelated donor bone marrow transplantation for children with Acute leukemia.
- Unrelated donor bone marrow transplantation for Acute leukemia in patients with Down''s syndrome.
- Irradiation of singly and doubly transduced murine neuroblastoma cells expressing B7-1 and producing interferon-gamma reduces their capacity to induce systemic immunity.
- Defective lymphocyte glycosidases in the macrophage activation cascade of juvenile osteopetrosis.
- Retroviral-mediated transfer of the murine interleukin-3 gene engineered for intracellular retention results in a Myeloproliferative syndrome but is associated with ci...
- Interleukin-2 gene transfer into murine neuroblastoma decreases tumorigenicity and enhances systemic immunity causing regression of preestablished retroperitoneal tumors.
- Transfection of the mouse ICAM-1 gene into murine neuroblastoma enhances susceptibility to lysis, reduces in vivo tumorigenicity and decreases ICAM-2-dependent killing.
- Dependency on intercellular adhesion molecule recognition and local interleukin-2 provision in generation of an in vivo CD8+ T-cell immune response to murine myeloid l...
- GM-CSF-induced internal autocrine proliferation occurs in a compartment outside of the endoplasmic reticulum.
- Predicting bleeding in common ear, nose, and throat procedures: a prospective study.
- Circulating macrophage colony-stimulating factor is not reduced in malignant osteopetrosis.
- B7-1 expression decreases tumorigenicity and induces partial systemic immunity to murine neuroblastoma deficient in major histocompatibility complex and costimulatory ...
- Carboxyl methylation of nonhistone chromosomal proteins.
- Haploidentical bone marrow transplantation for osteopetrosis.
- Pseudomonas sepsis simulating Acute promyelocytic leukemia.
- Treatment of haemangioendotheliomas with alpha interferon.
- Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis.
- Interleukin-2 secretion by transduced and unselected BDL-2 lymphoma results in increased survival in mice with previously established disseminated Disease.
- A prospective randomized trial of the anti-emetic efficacy of ondansetron and granisetron during bone marrow transplantation.
- Flt3 ligand antitumor activity in a murine breast cancer model: a comparison with granulocyte-macrophage colony-stimulating factor and a potential mechanism of action.
- Outcome of second hematopoietic cell transplantation in Hurler syndrome.
- Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta.
- High peripheral blood progenitor cell counts enable autologous backup before stem cell transplantation for malignant infantile osteopetrosis.
- N-acetyl-L-cysteine improves outcome of advanced cerebral adrenoleukodystrophy.
- Analysis of factors affecting development of carpal tunnel syndrome in patients with Hurler syndrome after hematopoietic cell transplantation.
- Combination of enzyme replacement and hematopoietic stem cell transplantation as therapy for Hurler syndrome.
- Growth and endocrine function in patients with Hurler syndrome after hematopoietic stem cell transplantation.
Schools
The Warren Alpert Medical School Of Brown University
University Of Wisconsin Madison
University Of Minnesota
Procedures Preformed
- Bone Marrow Transplant
Conditions Treated
- Acute Leukemia
- Anemia
- Graft vs Host Disease
- Myeloproliferative Disorders
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Awards
- Regional Top Doctor
- CMS Meaningful Use Stage 1 Certification
- Super Doctor
Education
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University of Minnesota at Fairview -
University of Wisconsin -
Warren Alpert Medical School of Brown University
Hospital
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University of Minnesota Medical Center, Fairview
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